With the rapid development of nanotechnology, more and more nanomaterials are inevitably directly or indirectly into the environmental media (such as water, soil, sediment, etc. And human health has unpredictable effects. Nano-titania (TiO2-NPs) and nano-zinc oxide (ZnO-NPs) are nano-metal oxides that were the first to achieve commercial production, the highest yield, the largest demand and the most widely used nano-materials. But so far, the research on the mechanism of action of its environmental behaviors affecting toxicological effects is still in its infancy, far behind its production applications.
Recently, the Xuan Group of Environmental Toxicology and Ecology Research Institute of Institute of Technology Biology and Agricultural Engineering, Chinese Academy of Sciences, Hefei Research Institute of Physical Chemistry has made new progress in the study of the effect of environmental factors on the physicochemical properties, occurrence state, and toxicological effects of nano-metal oxidation. .
The research group found that soluble and insoluble nano-metal oxides have different physiochemical properties and toxicity effects as the aging time prolongs: the aging process of nano-zinc oxide occurs, and its surface morphology, crystal structure and chemical composition Significant changes occurred, leading to a significant decrease in cytotoxicity, while its genetic toxicity showed an upward trend. In contrast, the aging process did not significantly affect the physical and chemical properties and toxic effects of nano-titanium dioxide. The study has been accepted and published by the International Journal of Toxicology, Nanotoxicology (13:1-11, 2015). The results of the study investigate the outcomes and toxic effects of nano-metal oxides in complex systems and their structure-activity relationships. Provides new clues and ideas.
The study was funded by the National Major Research Program, the Pilot Project of the Chinese Academy of Sciences, the National Natural Science Foundation, and the Dean's Fund.
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